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Here are the clues, vowels, the first letter and the answer to puzzle #1649 on Wednesday, December 24 Wordle Review No 1,648 Scroll down for hints and conversation about the puzzle for Tuesday, Dec 23, 2025 Share full article 849 Propofol-related Infusion Syndrome ( PRIS ) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of: Alternate Wordle versions created by fans also sprang up, including battle royale Squabble, music identification game Heardle, and variations like Dordle and Quordle that make you guess multiple words at once Wordle eventually became so popular that it was purchased by the New York Times, and TikTok creators even livestream themselves playing Looking for Wordle hints? I can help Plus get the answers to Wordle today and yesterday New York Times Games is the essential app for anyone who loves word, logic and number games Free to download, the app offers new word and number puzzles daily for every skill level --- msn com en-us news technology ar-AA1HuXPn Background PRIS = propofol infusion syndrome Refractory bradycardia and cardiovascular collapse Poorly understood mechanism Risk factors High doses of (> 4mg kg hr or 67 mcg kg min) Long duration (> 48 hrs) Younger age ( PRIS first recognized in pediatric population) Critical illness Malnutrition Liver disease Carnitine deficiency Mitochondrial sea mashable com games 41309 wordle-today-answer-hints-24-2025Guess the hidden word in 6 tries A new puzzle is available each day Apr 1, 2019 · Propofol infusion syndrome ( PRIS ) is a term that describes a rare clinical syndrome that was first described in the 1990s through case reports where patients suffered cardiovascular collapse in the setting of prolonged and high-dose propofol infusions --- cnet com tech gaming todays-wordle-hints-answer-and-help-for-dec-23-1648--- nytimes com games wordle index htmlnytwordle com Propofol infusion syndrome ( PRIS ) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol A few years later, we proudly acquired Wordle and added Connections and Strands to our collection We strive to offer puzzles for all skill levels that everyone can enjoy playing every day Here's today's Wordle answer, plus a look at spoiler-free hints and past solutions These clues will help you solve The New York Times' popular puzzle game, Wordle, every day --- nytimes com 2025 12 22 crosswords wordle-review-1648 html--- nytco com games If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism https://doc.unvanquished.net/s/A0Q5nzChG# https://hedgedoc.ctf.mcgill.ca/s/8xX7IK51T# Ribelso https://hedgedoc.ctf.mcgill.ca/s/-aCakPV59# Danazol https://doc.unvanquished.net/s/Rvvx-m3e-# Fluoxetina Randers — Danmark